OK, this one is a bit out there.
According to MIT Technology Review, a 36-year-old California woman effectively treated her chronic depression by surgically placing implants in her skull and receiving up to 300 electric zaps a day.
The zaps only occur during the day, so as to not stimulate her while sleeping.
… conducted the treatment, which requires a number of steps:
This treatment — known as deep brain stimulation — has already been used by 10s of thousands of Parkinson’s and epilepsy patients (the depression use case required an FDA exemption).
The reason: every person has different parts of their brain affected (hence the mapping). Also, the solution is currently not very scalable.
“It’s an invasive, expensive procedure that requires weeks of fine-tuning and a full day of surgery,” MIT Technology Review states.. “[So] it is only really suitable for those in whom other treatments have failed.”
Still, this out-there solution provides hope for those who have unsuccessfully tried everything else.